BRCA2, familial breast-ovarian cancer susceptibility 2

Treatment

Is there a treatment for Hereditary Breast and Ovarian Cancer caused by BRCA2 gene mutations?

There is no treatment that can cure Hereditary Breast and Ovarian Cancer (HBOC) syndrome. However, there are options available to reduce the risk of developing cancer. These options include:

  • Increased cancer screening
  • Risk-reducing surgery
  • Medications (Tamoxifen)
  • Lifestyle changes

The National Comprehensive Cancer Network has management guidelines for BRCA2 gene mutation carriers. These guidelines are updated frequently, so please review the current recommendations by visiting the National Comprehensive Cancer Network. Management recommendations vary by age. Talking with a healthcare provider with expertise in HBOC syndrome can help someone determine the best medical management and risk-reduction options for their situation.

References
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What can be done to reduce the risk for breast cancer caused by BRCA2 gene mutations?

What can be done to reduce the risk for ovarian cancer caused by BRCA2 gene mutations?

What can be done to reduce the risk for breast cancer caused by BRCA2 gene mutations?

In general, increased breast cancer screening may detect breast cancer at an earlier, more treatable stage. Increased breast cancer screening for women commonly involves clinical breast exams and an annual mammogram and breast MRI. Men who carry a BRCA2 mutation should receive annual clinical breast exams.

There are also options to lower the risk for breast and ovarian cancers. These options may include risk-reducing medications like Tamoxifen or preventive (prophylactic) surgery. Surgery is not for everyone and is a very personal choice. For women, a bilateral risk-reducing mastectomy (removal of both breasts) can greatly reduce the risk of developing breast cancer. A prophylactic salpingo-oophorectomy (removal of the ovaries and fallopian tubes), can also lower the risk for breast cancer in premenopausal women.

References
What can be done to reduce the risk for ovarian cancer caused by BRCA2 gene mutations?

Unfortunately, there are not good screening methods for ovarian cancer. For women, a prophylactic salpingo-oophorectomy (removal of the ovaries and fallopian tubes), can reduce the risk of ovarian cancer by 96%. This is why healthcare providers will more strongly recommend consideration of a bilateral salpingo- oophorectomy for women around 35-40 years of age who are done having children, or 40-45 years of age for women who have had a bilateral mastectomy. Healthcare providers may also recommend using medication, like birth control pills, to reduce ovarian cancer risk.

References

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