BRCA1, familial breast-ovarian cancer susceptibility 1

Treatment

Should men with a BRCA1 mutation have prostate cancer screening?

Prostate cancer screening is recommended for men who carry a BRCA1 mutation. Prostate cancer screening may be recommended to begin around age 40 for men with a BRCA1 gene mutation, which is a younger age than the screening recommendation for men in the general population. Men with a BRCA1 gene mutation should talk with their doctor about current screening guidelines.

References
  • National Comprehensive Cancer Network. Genetic/Familial High-Risk Assessment: Breast and Ovarian (Version 2.2016). https://www.nccn.org/professionals/physician_gls/pdf/genetics_screening.pdf.
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Can you screen for pancreatic cancer in you have a BRCA1 mutation?

Is there a treatment for Hereditary Breast and Ovarian Cancer syndrome?

What can be done to reduce the risk for breast cancer for people with a BRCA1 gene mutation?

What can be done to reduce the risk for ovarian cancer for people with a BRCA1 gene mutation?

Can you screen for pancreatic cancer in you have a BRCA1 mutation?

There are not any specific screening guidelines for pancreatic cancer, but screening may be individualized based on the cancers in the family.

References
  • National Comprehensive Cancer Network. Genetic/Familial High-Risk Assessment: Breast and Ovarian (Version 2.2016). https://www.nccn.org/professionals/physician_gls/pdf/genetics_screening.pdf.
Is there a treatment for Hereditary Breast and Ovarian Cancer syndrome?

There is no treatment that can cure Hereditary Breast and Ovarian Cancer (HBOC) syndrome. However, there are options available to reduce the risk of developing cancer. These options include:

  • Increased cancer screening
  • Risk-reducing surgery
  • Medications (Tamoxifen)
  • Life-style changes

The National Comprehensive Cancer Network has management guidelines for BRCA1 gene mutation carriers. These guidelines are updated frequently, so please review the current recommendations by visiting the National Comprehensive Cancer Network. Management recommendations vary by age. Talking with a healthcare provider with expertise in HBOC syndrome can help someone determine the best medical management and risk-reduction options for their situation.

What can be done to reduce the risk for breast cancer for people with a BRCA1 gene mutation?

In general, increased breast cancer screening may detect breast cancer at an earlier, more treatable stage. Increased breast cancer screening for women commonly involves clinical breast exams and an annual mammogram and breast MRI. Men who carry a BRCA1 mutation should receive annual clinical breast exams.

There are also options to lower the risk for breast and ovarian cancers. These options may include risk-reducing medications like Tamoxifen or preventive (prophylactic) surgery. Surgery is not for everyone and is a very personal choice. For women, a bilateral risk-reducing mastectomy (removal of both breasts) can greatly reduce the risk of developing breast cancer. A prophylactic salpingo-oophorectomy (removal of the ovaries and fallopian tubes), can also lower the risk for breast cancer in premenopausal women.

References
  • National Comprehensive Cancer Network. Genetic/Familial High-Risk Assessment: Breast and Ovarian (Version 2.2016). https://www.nccn.org/professionals/physician_gls/pdf/genetics_screening.pdf.
  • http://www.ncbi.nlm.nih.gov/books/NBK1247/
What can be done to reduce the risk for ovarian cancer for people with a BRCA1 gene mutation?

Unfortunately, there are not good screening methods for ovarian cancer. For women, a prophylactic salpingo-oophorectomy (removal of the ovaries and fallopian tubes), can reduce the risk of ovarian cancer by 96%. This is why healthcare providers will more strongly recommend consideration of a bilateral salpingo- oophorectomy for women around 35-40 years of age who are done having children, or 40-45 years of age for women who have had a bilateral mastectomy. Healthcare providers may also recommend using medication, like birth control pills, to reduce ovarian cancer risk.

References
  • http://www.ncbi.nlm.nih.gov/books/NBK1247/
  • National Comprehensive Cancer Network. Genetic/Familial High-Risk Assessment: Breast and Ovarian (Version 2.2016). https://www.nccn.org/professionals/physician_gls/pdf/genetics_screening.pdf.

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