Beta-thalassemia

Overview

What is Beta-thalassemia?

Beta thalassemia is a life-long disease. People with beta thalassemia have abnormal hemoglobin, which is a part of a red blood cell that carries oxygen to all areas of the body. In people with beta thalassemia, low levels of hemoglobin lead to a lack of oxygen in many parts of the body. Affected individuals also have a shortage of red blood cells (anemia), which can cause pale skin, weakness, fatigue, and more serious complications. Individuals with thalassemia often require frequent blood transfusions or hospitalization.

References
  • Beta-thalassemia. [Internet]. Genetics Home Reference. [updated September 2015].Available from: http://ghr.nlm.nih.gov/condition/beta-thalassemia.
  • Indian J Hum Genet. 2014 Apr;20(2):101-19. doi: 10.4103/0971-6866.142841.Guidelines for screening, diagnosis and management of hemoglobinopathies.Ghosh K1, Colah R1, Manglani M2, Choudhry VP3, Verma I4, Madan N5, Saxena R6, Jain D7, Marwaha N8, Das R9, Mohanty D10, Choudhary R11, Agarwal S12, Ghosh M13, Ross C14
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What is beta-thalassemia also called?

How common is beta thalassemia?

Are there different types of beta thalassemia?

What is the incidence of beta thalassemia in the world?

What is beta-thalassemia also called?

Beta-thalassemia is also known as Cooley's anemia and Mediterranean anemia. It may also be referred to as thalassemia major and thalassemia intermedia.

References
  • Cooley?s anemia foundation [Internet] [updated 2016]. Available from: http://cooleysanemia.org
  • Indian J Hum Genet. 2014 Apr;20(2):101-19. doi: 10.4103/0971-6866.142841.Guidelines for screening, diagnosis and management of hemoglobinopathies.Ghosh K1, Colah R1, Manglani M2, Choudhry VP3, Verma I4, Madan N5, Saxena R6, Jain D7, Marwaha N8, Das R9, Mohanty D10, Choudhary R11, Agarwal S12, Ghosh M13, Ross C14
How common is beta thalassemia?

Beta thalassemia is a common blood disorder worldwide. Thousands of infants with beta thalassemia are born each year. Beta thalassemia occurs most frequently in people from Mediterranean countries, North Africa, the Middle East, India, Central Asia, and Southeast Asia. The highest incidences of beta thalassemia are reported in Cyprus, Sardinia, and Southeast Asia.

References
  • Beta-thalassemia. [Internet]. Gene Reviews [updated May 14. 2015]. Available from: http://www.ncbi.nlm.nih.gov/books/NBK1426
  • Indian J Hum Genet. 2014 Apr;20(2):101-19. doi: 10.4103/0971-6866.142841.Guidelines for screening, diagnosis and management of hemoglobinopathies.Ghosh K1, Colah R1, Manglani M2, Choudhry VP3, Verma I4, Madan N5, Saxena R6, Jain D7, Marwaha N8, Das R9, Mohanty D10, Choudhary R11, Agarwal S12, Ghosh M13, Ross C14
Are there different types of beta thalassemia?

Beta thalassemia is classified into two types depending on the severity of symptoms: thalassemia major and thalassemia intermedia. Of the two types, thalassemia major is more severe.

References
What is the incidence of beta thalassemia in the world?

The estimated number of worldwide births of patients with beta thalassemia major every year is about 22,989. The total annual incidence of symptomatic individuals is estimated at 1 in 100,000 throughout the world.

References
  • Modell, B., Darlison, M. Global epidemiology of haemoglobin disorders and derived service indicators. Bull. World Health Organ. 2008; 86: 480-487.
  • Weatherall, D. J. The inherited diseases of hemoglobin are an emerging global health burden. Blood. 2010; 115: 4331-4336.

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