Acyl-coa dehydrogenase, very long-chain, deficiency of
Inheritance
How is Very Long-Chain Acyl-Coenzyme A Dehydrogenase Deficiency (VLCADD) inherited?
The way in which Very Long-Chain Acyl-Coenzyme A Dehydrogenase Deficiency (VLCADD) is inherited is called "autosomal recessive." This means that to be affected, a person must have a difference (mutation) in both copies of the ACADVL gene in each cell.
The parents of a child with VLCADD usually each carry one copy of the gene containing a mutation. The parents are referred to as carriers. Carriers do not show signs or symptoms of the condition. When two carriers of the same autosomal recessive condition have children, each child has a 25% (1 in 4) risk to have the condition, a 50% (1 in 2) risk to be a carrier like each of the parents, and a 25% (1 in 4) chance to not have the condition and not be a carrier.
In order to learn more about the genetics of VLCADD, people can speak with a genetic counselor. Genetic counselors can be found on the National Society of Genetic Counselors website.
References
- Leslie ND, Valencia CA, Strauss AW, et al. Very Long-Chain Acyl-Coenzyme A Dehydrogenase Deficiency. 2009 May 28 [Updated 2014 Sep 11]. In: Pagon RA, Adam MP, Ardinger HH, et al., editors. GeneReviews® [Internet]. Seattle (WA): University of Washington, Seattle; 1993-2016. http://www.ncbi.nlm.nih.gov/books/NBK6816/
- Genetic and Rare Disease Information Center (GARD). "VLCAD deficiency." Retrieved 1 June 2016. Available from: https://rarediseases.info.nih.gov/gard/5508/vlcad-deficiency/resources/1
